编译|冯维维 Science,科学 29 November 2024, Volume 386, Issue 6725 《科学》2024年11月29日,第386卷,出版6725期  生物学Biology Suppression of neurons in circumventricular organs enables months-long survival without water in thirteen-lined ground squirrels 这样做可让十三纹地松鼠在缺水情况下存活数月 ▲ 作者:MADELEINE S. JUNKINS,周论 NI Y. FENG, DANA K. MERRIMAN, SVIATOSLAV N. BAGRIANTSEV, AND ELENA O. GRACHEVA ▲链接 : https://www.science.org/doi/10.1126/science.adp8358 ▲摘要
: 任何经常锻炼的人都知道口渴是什么感觉 。这种对水的文导闻科强烈需求在哺乳动物中很常见
,并确保人们对水的读新生理需求得到满足。然而在冬眠的学网动物中 ,饮水和口渴会被抑制数月。科学 Junkins等人观察了十三纹地松鼠的出版这一现象,发现它们即使面对水分不足的周论生理指标
,也能持续数月的文导闻科抑制口渴。这种抑制是读新由脑室周围器官的神经元活性降低介导的,这些器官在冬季功能降低。学网 ▲ Abstract: Anyone who exercises regularly knows what it is 科学like to feel intensely thirsty. This powerful drive for water is common within mammals and ensures that our physiological need for water is met. In animals that hibernate, however, drinking and thirst are suppressed for months. Junkins et al. looked at this phenomenon in the thirteen-lined ground squirrel, a well-studied hibernating rodent, and found that their months-long suppression of thirst comes even in the face of physiological indicators of fluid deficit. This suppression is mediated by reduced activity of neurons in the circumventricular organs, which experience reduced function in winter. Exposure to sugar rationing in the first 1000 days of life protected against chronic disease 出生后头1000天接受糖配给,可预防慢性疾病 ▲ 作者 :TADEJA GRACNER,出版 CLAIRE BOONE, AND PAUL J. GERTLER ▲链接: https://www.science.org/doi/10.1126/science.adn5421 ▲摘要 : 作者利用1953年9月英国糖配给结束后的准实验变化,研究了怀孕后1000天内限制糖摄入对2型糖尿病和高血压的周论影响。配给制将糖的摄入量限制在当前膳食指南的范围内,配给制结束后,糖的摄入量几乎立即翻了一番
。 他们使用英国生物银行数据进行事件研究设计,比较定量配给结束前后怀孕的成年人
,发现早期定量配给使2型糖尿病和高血压的风险分别降低了35%和20%,并将疾病发病时间分别推迟了4年和2年 。 在子宫内接触糖的保护作用很明显 ,产后限制糖的保护作用增强 ,尤其是在6个月后,可能开始吃固体食物 。在子宫内,仅糖配给就占了风险降低的三分之一。 ▲ Abstract
: We examined the impact of exposure to sugar restrictions within 1000 days after conception on type 2 diabetes and hypertension, leveraging quasi-experimental variation from the end of the United Kingdom’s sugar rationing in September 1953. Rationing restricted sugar intake to levels within current dietary guidelines, and consumption nearly doubled immediately after rationing ended. Using an event study design with UK Biobank data comparing adults conceived just before or after rationing ended, we found that early-life rationing reduced type 2 diabetes and hypertension risk by about 35 and 20% and delayed disease onset by 4 and 2 years, respectively. Protection was evident with in utero exposure and increased with postnatal sugar restriction, especially after 6 months, when eating of solid foods likely began. In utero sugar rationing alone accounted for about one-third of the risk reduction. 信息学和机器人Informatics & Robotics Misinformation exploits outrage to spread online 虚假信息利用愤怒在网上传播 ▲ 作者
:KILLIAN L. MCLOUGHLIN, WILLIAM J. BRADY, ADEN GOOLSBEE, BEN KAISER, KATE KLONICK, AND M. J. CROCKETT ▲链接 : https://www.science.org/doi/10.1126/science.adl2829 ▲摘要: 虚假信息仍然是对民主完整性 、国家安全和公共卫生的重大威胁
。然而,社交媒体平台难以遏制有害但吸引人的内容的传播
。在不同平台上,作者研究了情绪,特别是道德义愤(厌恶和愤怒的混合)在错误信息传播中的作用。 与可靠的新闻来源相比,来自虚假信息来源的帖子引起的愤怒反应和愤怒多于快乐或悲伤的情绪。用户被激励去转发那些引起愤怒的内容 ,并且在没有先阅读内容以辨别其准确性的情况下进行分享。仅仅强调准确分享的干预措施可能无法遏制错误信息 ,因为用户可能会分享令人发指的
、不准确的内容,以表明他们的道德立场或对政治团体的忠诚 |